Bioenergetic Approaches and inflammation of MPTP Toxicity

Abstract

We are continuing to examine a number of neuroprotective agents in an MPTP model of PD. We are also continuing to utilize metabolomic profiling to identify novel biomarkers for PD and to investigate whether these occur in animal models of PD. We are continuing to develop and characterize a new animal model of PD by making a knock out of PlNK1, a nuclear encoded kinase localized to mitochondria, and which causes autosomal recessive PD. We have completed a study of the effects of human dopaminergic stem cells in a 6-hydroxy dopamine model of PD.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2008
Accession Number
ADA490306

Entities

People

  • M. F. Beal

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cells
  • Department Of Defense
  • Inflammation
  • Information Operations
  • Maryland
  • Neuroprotective Drugs
  • New York
  • Stem Cells
  • Toxicity
  • Universities

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.

Technology Areas

  • Biotechnology