Development of Nanomechanical Sensors for Breast Cancer Biomarkers
Abstract
Nanotechnology has the potential to develop silicon-based arrays for sensing biomarkers associated with breast cancer. In order to develop patient-specific therapy tailored for each individual parallel detection of a large number (`103-104) biomarkers may be required. The experience of the semiconductor industry in developing large scale integrated circuits at very lost cost can lead to similar breakthroughs in array sensors for biomolecules of interest to the breast cancer community. Nanotechnology can meet the need for high throughput sensitive methods for rapidly recording biomarker profiles of tumors in individual patients. We report results on the development of arrays of conductance sensors of biofunctionalized silicon nanowires. The fractional change is greatest for the smallest sensors due to the increased surface-to-volume ratio. The fabrication of arrays of conductance based sensors has now been done and the nanosensors have been characterized using model systems. This work sets the path for translation of the fabricated sensors to breast cancer clinical practice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2008
- Accession Number
- ADA490342
Entities
People
- Shyamsunder Erramilli
Organizations
- Boston University