The Loss of Pin1 Deregulates Cell Cycle Progression and Promotes the Development of Breast Cancer
Abstract
Pin1 regulates many factors that are relevant to breast cancer, such as c-Jun, c-Myc, cyclin D1, and cyclin E. However the function of Pin1 in a normal cell is still poorly understood. Thus the role of Pin1 in G0/G1 to S-phase progression of the cell cycle was examined in this research project. The most significant finding was that Pin1 appears to be a novel regulator of the Rb signaling pathway.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2008
- Accession Number
- ADA490639
Entities
People
- Brian Lew
Organizations
- Duke University