A Placebo-Controlled Trial of Prazosin vs. Paroxetine in Combat Stress-Induced PTSD Nightmares and Sleep Disturbance

Abstract

The primary goal of this proposal is to evaluate the efficacy and tolerability of the alpha-1 adrenergic antagonist prazosin compared to placebo for combat trauma-related nightmares, sleep disturbance and overall function in recently combat-exposed returnees from OIF and OEF. A secondary goal is to evaluate the effects of the SSRI paroxetine on behavioral symptoms and overall function in this population. Specific hypotheses (described below) will be tested in a three parallel arm 12-week randomized controlled trial of prazosin, paroxetine and placebo in combat-exposed troops recently returned from OIF and OEF with combat trauma-related persistent nightmares and sleep disturbance. This will be a two-site study performed in the Seattle/Tacoma area at Madigan AMC and in the Washington DC area at Walter Reed AMC.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2008
Accession Number
ADA490652

Entities

People

  • Charles Engel
  • Elaine Peskind
  • Kris Peterson
  • Michael Doyle
  • Miles Mcfall
  • Murray A. Raskind

Organizations

  • Seattle Institute for Biomedical and Clinical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Behavior And Behavior Mechanisms
  • Biomedical Research
  • Clinical Trials
  • Combat Injuries
  • Data Management
  • Databases
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Health Care
  • Health Services
  • Human Behavior
  • Hypotheses
  • Information Operations
  • Puget Sound
  • Statistical Analysis
  • Training

Fields of Study

  • Psychology

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.