Changes in Ovarian Stromal Function and Associated Symptoms in Premenopausal Women Undergoing Chemotherapy for Breast Cancer
Abstract
The objective of this pilot study is to identify whether androgen levels are adversely affected by adjuvant chemotherapy for breast cancer, and whether low androgen levels are correlated with the frequency and severity of fatigue, weight gain, psychological symptoms, vasomotor symptoms, and libido. A longitudinal, descriptive design will be used with questionnaires completed and blood drawn from 20 premenopausal women at four time periods: baseline (before treatment), mid-treatment, immediate post-treatment, and 6 months later. Questionnaires include the Female Sexual Function Index, Greene Climacteric Scale, Profile of Mood States, Schwartz Fatigue Scale, and a menses diary. Data analysis will involve descriptive statistics and plots of hormone levels over time as well as t-tests to examine changes in hormone levels. Correlational analysis will be done to look at the relationship of symptoms to hormone levels. The authors have currently enrolled 20 eligible women, 18 of whom have completed all study components. If a connection between low levels of androgens and symptoms is found, androgen replacement may be a viable treatment option for breast cancer survivors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2007
- Accession Number
- ADA491082
Entities
People
- Ann E. Kearns
- Charles L. Loprinzi
- Debra L. Barton
- Jeff A. Sloan
- Marlene H. Frost
Organizations
- Mayo Clinic