Modifiers of the Efficacy of Risk-Reducing Salpingo-Oophorectomy for the Prevention of Breast and Ovarian Cancer in Carriers of BRCA1 and BRCA2 Mutations
Abstract
The principle investigator was funded via a Physician-Scientist Training Award to participate in a comprehensive training plan to foster the transition to independent clinical breast cancer researcher. This plan included: 1) conduct of a prospective study examining modifiers of the efficacy of risk-reducing salpingo-oophorectomy (RRSO) for the prevention of breast and ovarian cancer in carriers of BRCA mutations; and 2) participation in a structured training program in research methodology, biostatistics, molecular biology, and ethics. Progress from 5/1/2007 4/30/2008 includes: a) Publication of the first prospective data examining the efficacy of RRSO for the prevention of BRCA-associated breast and gynecologic cancer when BRCA2 mutation carriers are examined separately from BRCA1 mutation carriers.(Kauff ND, et al. J Clin Oncol 2008;26:1331-7); b) Continuation of training in genetic epidemiology, outcomes analysis, and conduct of clinical research, through formal mentoring and participation in the laboratory meetings of Kenneth Offit, MD, MPH; c) Submission as Co-PI of a grant application to the Breast Cancer Alliance to model the risk for 2nd primary breast cancer in individuals with BRCA-negative familial breast cancer; and d) Submission as Co-PI a SPORE project application to evaluate the role of BRCA dysfunction in primary and secondary prevention of epithelial ovarian cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2008
- Accession Number
- ADA491172
Entities
People
- Noah D. Kauff
Organizations
- Memorial Sloan Kettering Cancer Center