Inflammatory Markers and Breast Cancer Risk

Abstract

Mammographic breast density is one of the strongest risk factors identified for breast cancer, and a marker of cancer risk for both breasts. To gain further insight into the role of inflammatory cytokines in the etiology of breast density, this study investigates associations between serum cytokine levels, genetic variation in cytokine genes, and breast density. This report provides information on the progress made during the second year of the grant. It should be noted that only in January 2008 Dr. Diergaarde officially became the PI of this award and that no monies could be spent until this change in PI was official. This did affect our progress this year. A study specific database was created and we have started analyzing the serum cytokine data received from Dr. Tracy s laboratory. SNPs were selected for genotyping: candidate functional SNPs were identified from the literature and databases such as SeattleSNPs; tagSNPs were selected using data from HapMap and the HaploView/Tagger program. We are currently genotyping the MAMS samples using the iPLEX Gold assay (Sequenom).

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2008
Accession Number
ADA491235

Entities

People

  • Brenda Diergaarde

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Buildings And Structures
  • Cell Physiological Processes
  • Chemical Compounds
  • Chemistry
  • Chi Square Test
  • Data Science
  • Databases
  • Department Of Defense
  • Diseases And Disorders
  • Genetic Variation
  • Information Science
  • Mass Spectrometry
  • Neoplasms
  • Numbers
  • Square Roots

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology