Laser Induced Millimeter Wave Fluorescence From Bio-Materials
Abstract
In this report, we conduct the initial theoretical investigation of emission of radiation by DNA components upon the absorption of infrared (IR) radiation. Excitation wavelengths in 9 and 11 urn region are of interest. These transitions are related to the bond vibrations including only small groups of atoms. Hence, it is possible to analyze different fragments of DNA for identification of proper transitions. The carbon dioxide (CO2) laser was chosen as the IR radiation source. We calculated the vibrational spectra of various DNA bases: cytosine; thymine; adeninc; and guanine along with 2' deoxyadenosine 5'-monophosphate (dAMP); 2' deoxyguanosine 5'-monophosphate (dGMP); 2' deoxycytidine 5'-monophosphate (dCMP); 2' deoxythymidine 5'-monophosphate (dTMP) with HF/6-31G (d)\ and B3LYP approximation. The theoretical model considers the molecule as a system of coupled oscillators. The anharmonicity couples the oscillators and drives the energy transfer. Anharmonicity triggered transitions are analyzed. The Fermi resonances provide the most effective channels of the energy transfer. The probabilities of Fermi resonance induced transitions arc calculated for the absorption bands evaluated with the HF model. We also acquired absorption spectra of DNA components from a herring sperm DNA sample. The tunable C02 laser induced emission spectra of these bio-chemicals was also acquired.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2008
- Accession Number
- ADA491480
Entities
People
- Ashish Tripathi
- Boris Gelmont
- Raphael P. Moon
Organizations
- Edgewood Chemical Biological Center