Estrogen-Induced Depurination of DNA: A Novel Target for Breast Cancer Prevention

Abstract

The research conducted in this COE grant is based on the paradigm that estrogens can become endogenous carcinogens when their metabolism is unbalanced, favoring formation of catechol estrogen quinones and their reaction with DNA. Compelling evidence obtained in the various specific aims of this COE will be decisive for determining the risk of breast cancer by using the depurinating estrogen-DNA adducts as biomarkers. These biomarkers will also be used for evaluating the ability of specific antioxidants to prevent breast cancer initiation. Much of the research accomplished by this COE was published in a review article in BBA-Reviews in Cancer, which was co-authored by all the participants of the COE.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2008
Accession Number
ADA491583

Entities

People

  • Ercole L. Cavalieri

Organizations

  • University of Nebraska Medical Center

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Capillary Electrophoresis
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Health Services
  • Liquid Chromatography
  • Mass Spectrometry
  • Neoplasms
  • Oncology
  • Organic Chemistry

Fields of Study

  • Chemistry

Readers

  • Defense Technology Research and Development.
  • Molecular and genetic basis of cancer.
  • Theoretical Analysis.