The Role of ADAM-15 Disintegrin in E-cadherin Proteolysis in Prostate Cancer Metastasis

Abstract

The primary goal of this proposal was to demonstrate that the membrane disintegrin, ADAM-15, could E-cadherin in prostate cancer cells, and that in this regard ADAM-15 would promote the metastatic growth of prostate cancer. The successful completion of this study has led to the confirmation of the functional role of ADAM15 in the cleavage of E-cadherin and metastatic growth of prostate cancer cells. These results justify continuing studies examining the metalloproteinase domain of ADAM15 as a direct therapeutic target for metastatic prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2008
Accession Number
ADA491608

Entities

People

  • Mark L. Day

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Media
  • Department Of Defense
  • Endothelial Cells
  • Epithelial Cells
  • Medical Personnel
  • Metastasis
  • Neoplasms
  • Peptides
  • Prostate
  • Prostate Cancer

Readers

  • Business Analytics
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).