Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer

Abstract

We explored the relationship between androgen withdrawal as an event that initiates a cascade promoting the development of androgen-independent prostate cancer through neuroendocrine progression. We define the early post-castration molecular events and linked androgen-deprivation therapy to the activation of non-receptor tyrosine kinases that promote androgen-independent growth and migration. We developed an animal model to validate this hypothesis that metastasize in SCID mice. We found that deregulation through non-receptor tyrosine kinases was blocked by Src-specific inhibitor AZD0530. We found this inhibited 100% of metastasis in an animal model. The translational benefit of this study was that through a National Cancer Institute sponsored trial, the drug is being tested for hormone refractory prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2008
Accession Number
ADA492892

Entities

People

  • Christopher P Evans

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Oncology
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Prostate Cancer Biology.