Exploiting a Molecular Gleason Grade for Prostate Cancer Therapy
Abstract
The Purpose of this proposal is to exploit a molecular correlate of the Gleason grading system for prostate carcinoma in order to: a) develop improved outcome predictors; and b) identify therapeutic strategies. The Scope of the project involves a tissue and blood-based analysis of candidate cancer grade-discriminatory markers in terms of their sensitivity specificity and outcome associations. The Major Findings to date demonstrated that molecular alterations measured at the transcript level can be verified to occur at the protein level and have the potential to be used as prognostic, treatment stratifying markers (e.g.TMPRSS2). We have also shown that grade associated proteins can be detected in the blood of men with prostate cancer. However to date the proteins we have evaluated (e.g. OPN) discriminate advanced metastatic disease from localized disease rather than high grade from low-grade cancers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2008
- Accession Number
- ADA493175
Entities
People
- Peter S Nelson
Organizations
- Fred Hutchinson Cancer Center