An Evaluation of Stereoscopic Digital Mammography for Earlier Detection of Breast Cancer and Reduced Rate of Recall
Abstract
The goal of this project was to evaluate in a screening context stereoscopic digital mammography versus standard (non-stereo) digital mammography for earlier detection of breast lesions during screening and for reduction in the rate of patient recall for further work-up. We enrolled 1458 patients at elevated risk for the development of breast cancer into the clinical trial. Each patient received both a standard screening examination and a stereoscopic screening examination which were read independently by different radiologists. If a suspicious finding was reported from either reading the patient was recalled for standard clinical workup examinations which formed the basis for lesion truth. Compared to standard digital mammography stereo mammography significantly reduced false positive lesion detections by 46% (p< 0.0001) and significantly increased true positive lesion detections by 23% (p< 0.05). ROC analysis of the readers judgments of the likelihood that a reported finding is real showed significantly greater accuracy for stereo Az = 0.94 than for standard Az = 0.85 (p=0.004).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2008
- Accession Number
- ADA493420
Entities
People
- David J. Getty
Organizations
- BBN Technologies