Development of Antibodies Against Novel Cell Surface Proteins in Hormone Refractory Prostate Cancer
Abstract
N-cadherin is a cell surface marker that is overexpressed in hormone refractory prostate cancer and targeting this protein either diagnostically or therapeutically may have clinical utility. We initially observed that the cadherin profiles of certain prostate cancer cell lines and xenografts correlated with their level of invasiveness. In addition, we saw that amongst certain hormone refractory xenograft models, there was a consistent upregulation of N-cadherin when compared to its androgen dependent counterpart. We generated specific monoclonal antibodies against different domains of N-cadherin in an attempt to determine if blockade could decrease invasion and metastasis. For the second year of the grant, there has been an increased focus on the in vitro and in vivo effects of two specific antibodies that were generated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2008
- Accession Number
- ADA493450
Entities
People
- Zev A. Wainberg
Organizations
- University of California, Los Angeles