Identify in Breast Cancer Stem Cell-Like Cells the Proteins Involved in Non- Homologous End Joining DNA Repair
Abstract
Breast cancer stem cells exist in several breast cancer cell lines based on recognized surface marker CD44+/CD24 or low or Hoechst efflux/ABCG2. The increased radiation resistance of breast cancer stem-like cells (CD44+/CD24 or low) was found in MCF-7, HCC1937, and MDA-MB-231 cells lines. The differential radiation resistance among the subpopulation might not rely on the NHEJ activity. Differential activation of ATM pathway could contribute to differential radiation resistance among the subpopulations of breast cancer cell lines. However, the inhibition of ATM activation blocked the growth more significantly in non stem-like cells than in stem-like cells after radiation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2008
- Accession Number
- ADA493642
Entities
People
- Hong Yin
Organizations
- Louisiana State University