Role of X-linked Inhibitor of Apoptosis in Breast Cancer

Abstract

XIAP is an exciting potential target for breast cancer therapeutics, but the specific functions of XIAP that contribute to breast cancer development or progression remain unknown. This project seeks to identify the properties of XIAP that play a crucial role in breast cancer, using mutated XIAP molecules that are deficient in specific cellular functions in both in vitro and in vivo models of breast cancer. In this phase of this project, cell lines deficient in XIAP have been evaluated to identify the role of XIAP in tumorigenesis, using models of anchorage-independent growth or tumor formation in immunocompromised mice. Understanding the effects of XIAP on tumor growth will a valuable guide in the development of therapeutics that specifically target tumor-related functions of XIAP and in the advancement of our understanding of breast cancer biology.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2008
Accession Number
ADA493644

Entities

People

  • Karolyn Oetjen

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Inhibitors
  • Molecules
  • Neoplasms
  • Proteins
  • Sequences
  • Targets
  • Therapy

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics