Environmentally Induced Gene Silencing in Breast Cancer

Abstract

The main goal of the study was to test the hypothesis that a reduction in gene expression could induce gene silencing (i.e. relatively stable loss of gene expression) in breast cells. Silencing of a variety of tumor suppressor genes plays a major role in the initiation and progression of breast cancer. Our ultimate goal is to determine if environmentally induced gene repression plays a role as a trigger for the silencing of genes. The purpose of the work described below was to confirm or refute the hypothesis.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2008
Accession Number
ADA493645

Entities

People

  • Mitchell Turker

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Experimental Design
  • Frequency
  • Gene Expression
  • Genes
  • Genetics
  • Information Operations
  • Methylation
  • Neoplasms
  • Suppressors
  • Tumor Cell Line

Readers

  • Molecular and genetic basis of cancer.