PSMA-Targeted Nano-Conjugates as Dual-Modality (MRI/PET) Imaging Probes for the Non-Invasive Detection of Prostate Cancer
Abstract
The goal of this project is to develop dual modality imaging probes for the detection of prostate cancer by doping radioisotopes to iron oxide nanoparticles, so that the sensitivity and specificity of prostate cancer diagnosis could be significantly improved. In the three years, a facile approach has been developed to prepare gamma- or positron emitting nuclides incorporated SPIO nanoparticles (NUSPIONs) for dual modality imaging of prostate cancer, where a size-exclusion filtration method was introduced to expedite the preparation while maintaining the narrow size-distribution, high radiochemical purity, and consequently the uniform physical and chemical properties. The NUSPIONs were highly stable in vivo and showed high tumor-to-muscle ratio (12.2 4.8 %ID/g at 24 h p.i.) in a prostate cancer xenograft model. Preliminary MR and autoradiography images with 177Lu-NUSPIONs in nude mice bearing PC-3 tumors clearly showed tumors implanted in the flanks, indicating the potential application of such nanoplatforms for the noninvasive dual modality imaging of prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2008
- Accession Number
- ADA493649
Entities
People
- Xiankai Sun
Organizations
- University of Texas at Dallas