Role of ADAM15 in Tumor/Endothelial Interactions Prostate Cancer Regression

Abstract

The primary purpose of this proposal was to demonstrate that the membrane disintegrin, ADAM-15 mediates the interaction (binding) between prostate tumor cells and vascular endothelium and that in this regard ADAM-15 would support the metastatic spread of human prostate cancer. The successful completion of one of the earliest aspects of this proposal has given substance to the hypothesis and confidence as we move ahead with more functional analysis of this mechanism. These results clearly justify continuing with the proposed studies and may ultimately justify ADAM15 as a direct therapeutic target for metastatic prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2008
Accession Number
ADA493686

Entities

People

  • Mark L. Day

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Biomedical Research
  • Blood
  • Blood Coagulation Factors
  • Blood Vessels
  • Cancer
  • Cardiovascular System
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Endothelial Cells
  • Endothelium
  • Neoplasms
  • Peptides
  • Prostate
  • Prostate Cancer
  • Vascular Endothelium

Readers

  • Military History of the United States in the 20th Century.
  • Oncology (Cancer Research).