Curcumin-Combretastatin Nanocells as Breast Cancer Cytotoxic and Antiangiogenic Agent
Abstract
The focus of our concept was to develop a novel therapeutical nanodevice aiming to deliver the anticancer natural compound curcumin specifically to breast cancer cells. We have successfully fabricated two kinds of nanocarriers, the single-walled carbon nanotubes (SWCNT) and the colloidal nanogels, and loaded them with curcumin. We have demonstrated that while the nanocarriers themselves are non-toxic to the breast cancer cells, the loaded nanoconstructs are significantly more cytotoxic than curcumin alone, in particular, in nanogel formulation. Our future research will focus on targeting the curcumin-loaded nanoconstructs with the antibodies against breast cancer cells surface receptors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2008
- Accession Number
- ADA494015
Entities
People
- Anna E. Reeves
- Eric Wickstrom
- Serguei V. Vinogradov