Development of a Gene Therapy Trial for Metastatic Prostate Cancer

Abstract

This award was to support the infrastructure and development of a Phase I clinical trial for men with metastatic prostate cancer. The Phase I trial under development employs a prostate restricted replicative adenovirus (PRRA) with excellent preclinical performance in vitro and in vivo in relevant animal models of human prostate cancer. Several components of the statement of work for this award have been completed. The key component of this trial the PRRA, AdIU1, required a slight modification before proceeding with implementation of the trial as submitted. Reconfirmation of the activity of the modified AdIU1 was required prior to moving forward with the clinical trial. Currently with the clinical trial team in place and modified AdIU1 verified and two additional potential prostate cancer therapeutics have been identified further applications to advance this clinical trial program are being prepared.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2008
Accession Number
ADA494544

Entities

People

  • Thomas A. Gardner

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Cell Physiological Processes
  • Chemistry
  • Clinical Trials
  • Culture Techniques
  • Diseases And Disorders
  • Gene Therapy
  • Indicator Dyes
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Programmed Cell Death
  • Prostate Cancer
  • Proteins
  • Therapy
  • Tissues
  • Viruses

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech