Prostate Cancer and Pesticide Exposure in Diverse Populations in California's Central Valley
Abstract
This project is a pilot case-control study of pesticide exposure and prostate cancer, that (1) poor measurement of pesticide exposure in studies of prostate cancer risk factors explains null findings to date; (2) a proposed method of recruiting and approaching cases and controls to a large population-based case-control study will result in acceptable response rates, but also will be biased; (3) We will be able to obtain sufficient DNA from mailed buccal swab kits to assess effect modification by known relevant genes, and have sufficient stored DNA to assess the impact of genes that may be discovered in future. We found that there are substantial increased risks of prostate cancer with long term exposure to a number of pesticides, despite the limitations of our pilot study (namely, small sample size). We addressed selection bias, and after doing so, still noted increased risks for prostate cancer with certain pesticides. Our study design appears to ensure that a large scale study would both be successful, and is warranted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2008
- Accession Number
- ADA494594
Entities
People
- Myles Cockburn
Organizations
- University of Southern California