Derivation of Human Lethal Doses

Abstract

Human lethal dose estimates are required, in conjunction with U.S. Army Military Exposure Guideline concentrations, to provide toxicity benchmarks for evaluation of candidate toxicity sensors for an Environmental Sentinel Biomonitor (ESB) system for drinking water protection. An approach was developed to estimate human lethal doses (lowest lethal dose - LD) for 26 Lo chemicals having varying amounts and qualities of toxicological data. Readily available toxicokinetic information was used to adjust the human lethal doses for uptake via drinking water consumed over the course of a day. Research recommendations are provided to improve LD Lo estimation approaches.

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Document Details

Document Type
Technical Report
Publication Date
Jan 19, 2006
Accession Number
ADA494706

Entities

Organizations

  • U.S. Army Center for Environmental Health Research

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Chemistry
  • Environmental Health
  • Environmental Protection
  • Health Services
  • Herbicides
  • Hydroxides
  • Hygiene
  • Industrial Hygiene
  • Laboratory Animals
  • Lethal Dosage
  • Occupational Safety And Health
  • Pesticides
  • Pharmacology
  • Public Health
  • Rodents
  • Therapy

Fields of Study

  • Agricultural and Food sciences

Readers

  • Environmental Engineering.
  • Sensor Fusion and Tracking Systems.
  • Toxicology/Environmental Toxicology