Telomere Length Polymorphisms: A Potential Factor Underlying Increased Risk of Prostate Cancer in African American Men and Familial Prostate Cancer

Abstract

This project tests the hypothesis that inherited and/or acquired differences in telomere length unprostate cancer observed in African Americans compared to Caucasians and in affected members of hefamilies. To test this hypothesis, telomere content in genomic DNA isolated from blood samples of by quantitative PCR and the data assessed for associations with either racial background or prostathe period of this report we have isolated genomic DNA from 128 members from affected and unaffectBuffy coat has been isolated from anonymous cord blood donor samples collected from newborns of diDNA has been isolated form these samples. We are currently still awaiting receipt of the mid-life Health Professionals Follow-up Study based at Harvard University. Analysis of the telomere lengthsgenomic DNA samples reveals that telomere lengths are shorter in affected compared with non-affecta statistically significant difference (p=0.026). This result supports the hypothesis that telomerdevelopment of prostate cancer within families displaying elevated risk.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2008
Accession Number
ADA494964

Entities

People

  • Alan K Meeker

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • African Americans
  • Biology
  • Biomedical Research
  • Caucasians
  • Cells
  • Chromosome Structures
  • Department Of Defense
  • Diseases And Disorders
  • Genetics
  • Health
  • Neoplasms
  • Procurement
  • Prostate
  • Prostate Cancer
  • Public Health
  • Standards
  • Universities

Fields of Study

  • Biology

Readers

  • Gender and Food Studies
  • Housing Policy Studies in Military Families with Privatization and Telomerase Allowance Units, Multi-Family Housing, and Telomere Lengths.
  • Molecular and genetic basis of cancer.