A Beta-Amino Acid Pyrokinin Analog Induces Irregular Pupariation Behavior in Larvae of the Flesh Fly Sarcophaga bullata
Abstract
The developmental process of pupariation is accelerated by members of the pyrokinin class of neuropeptides in larvae of the flesh fly Sarcophaga bullata. A pyrokinin analog (Ac-Y[beta3Phe]TPRLamide), in which a Phe residue is replaced with a beta-amino acid, accelerates pupariation in this fly at a potency (0.2 pmol/larva) that matches that of the native pyrokinin factor. At higher concentrations, this beta-amino acid pyrokinin analog induces irregular pupariation behavior patterns that are suggestive of neurotoxic properties. Biostable analogs based on this structure may in future provide analog leads with the potential to disrupt the important pupariation process in flies.)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2008
- Accession Number
- ADA495160
Entities
People
- Allison Strey
- Howard Williams
- Jan Zdarek
- Pawel Zubrzak
- Ronald J. Nachman