Dissecting Androgen-Dependent and Independent Signaling Pathways Using RNA Interference-Based Functional Genomics in Human Cells

Abstract

We had previously identified androgen responsive genes in LNCaP prostate cancer cells using microarray technology. I have performed a high throughput loss of function screen using RNA interference (RNAi) in order to identify androgen responsive genes that are critical for androgen induced proliferation. I am currently validating the candidate genes identified in my screen, and investigating whether they function in prostate tumor progression. When completed, my studies will lead to the identification and characterization of androgen regulated genes involved in prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2008
Accession Number
ADA495676

Entities

People

  • Isil Guney

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Androgen Receptors
  • Androgens
  • Biological Sciences
  • Biomedical Research
  • Cell Line
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Epithelial Cells
  • Genes
  • Hormones
  • Identification
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Throughput

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Prostate Cancer Biology.