Gold Nanoparticle Contrast Agents in Mammography: A Feasibility Study

Abstract

The successful translation of molecular imaging to mammography and digital breast tomosynthesis would allow clinical molecular imaging of the breast. This is a potentially more sensitive approach to early breast cancer detection, especially in women at high risk. Bioconjugated gold (Au) nanoparticle (NP) imaging agents, used in conjunction with digital mammography and breast tomosynthesis, should provide improved lesion conspicuity. Au-NP are exceptionally attenuating at mammographic energies; even very low concentrations are theoretically detectable. The primary aim of this study was to prove that Au-NP can act as a viable mammographic contrast agent. We successfully synthesized bioconjugated HER2/neu Au-NP. Using a multifunctionalization method with PEG and an anti-Her2 neu affibody, we were able to create nanoparticles which were stable in serum. These data are sufficient to begin in vitro studies to determine whether mammography molecular imaging agents are feasible.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2008
Accession Number
ADA495772

Entities

People

  • Andrew D. A. Maidment

Organizations

  • University of Pennsylvania

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Blood
  • Breast Cancer
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Detectors
  • Diagnostic Imaging
  • Electromagnetic Fields
  • Electron Microscopy
  • Imaging Techniques
  • Medical Personnel
  • Metallic Nanoparticles
  • Nanoparticles
  • Photoacoustic Tomography
  • Surface Plasmon Resonance
  • Tomography

Fields of Study

  • Medicine
  • Physics

Readers

  • Medical Imaging.
  • Nanocomposite Materials Science
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech