Lysosome-mediated Cell Death and Autophagy-Dependent Multidrug Resistance in Breast Cancer

Abstract

The original Statement of Work called for analysis of proteins and organelles involved in autophagic cell death (Task 1); for analysis of expression profiles and identification of pathways affected by tamoxifen treatment in parental cells and in resistant derivatives (Task 2); and for functional testing of identified differentially regulated genes as potential components of regulatory pathways for autophagy-related cell death (Task 3). It is important to recognize that Tasks 1 and 2 are parallel lines of investigation, so that Task 2 does not depend on completion of Task 1, and reversal of the timing of their execution does not affect execution of the overall project. By its nature Task 1 requires significant commitment of time (18 months projected) and is best performed by the same individual; on the contrary, Task 2 is associated mostly with analysis of data generated by expression profiling. Due to unforeseen delays, task 2 was begun before task 1.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2008
Accession Number
ADA495800

Entities

People

  • Victor V. Levenson

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alkenes
  • Autophagy
  • Biology
  • Blood Coagulation
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Chemistry
  • Data Analysis
  • Electronic Mail
  • Endoplasmic Reticulum
  • Identification
  • Metabolism
  • Organelles
  • Programmed Cell Death
  • Web Browsers

Readers

  • Instructional Design and Training Evaluation.
  • Molecular and Cellular Biology
  • Oncology (Cancer Research).