The Bone Marrow Stem Cell Origin of Human Breast Cancer Using Transgenic Mouse Models
Abstract
There is emerging evidence that transformed stem cells may be the source of human cancers. We felt that transgenic mouse models were ideally suited to examine this question and proposed to conduct marrow transplant experiments to test whether marrow stem cells are the cells of breast cancer origin. Our most significant findings included: 1) the demonstration that stromal cells within the transgenic breast cancers contain significant percentages of tissue macrophages, lymphocytes, fibroblasts, myofibroblasts and endothelial cells, which presumably represent the progeny of cancer-promoting stem cells of donor origin; 2) the demonstration that these stromal cells of donor origin may affect breast cancer progression differently than those of endogenous breast origin; 3)the demonstration that rare cancer-initiating stem cells of donor origin can give rise to breast cancer; and 4) the demonstration that these ectopically-derived stem cells that transform to breast cancer may be different biologically compared to the endogenous breast stem cells that spontaneously transform to breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2008
- Accession Number
- ADA495844
Entities
People
- Sanford H. Barsky
Organizations
- Ohio State University