Interfering with DNA Damage Signals: Radiosensitizing Prostate Cancer Using Small Peptides
Abstract
The major goal of this project is to identify small inhibitory peptides that can target critical DNA damage responsive pathways in order to develop novel therapeutic agents for prostate cancer radiotherapy. Previously we have demonstrated that small fusion peptides containing SMC1 phosphorylation and NBS1 ATM binding sequences can inhibit ATM activity and decrease prostate tumor cell clonogenic survival after radiation, therefore these peptides can be tested for in vivo activities of radiosensitization. In order to achieve this goal, we generated a series of tumor homing peptides containing these sequences and proved tumor specific targeting of the peptides. Ongoing experiments include approaches to reduce radiation damage to normal tissues and to evaluate of the fusion peptides as radiosensitizers in prostate cancer xenograft models.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2008
- Accession Number
- ADA497871
Entities
People
- Bo Xu
Organizations
- Southern Research