Rapid Discovery of Continuous-Performance Compounds and Powernap Compounds Through Large-Scale Mutagenesis in Drosophila

Abstract

This Phase II proposal (G. Tononi-PI) resulted from the combination of two independent projects in Phase I: "Rapid discovery of continuous performance and power-nap compounds through large-scale mutagenesis in Drosophila" (G. Tononi-PI, C. Cirelli-CoPI) and "Avian models of sustained wakefulness" (R. Benca-PI, N. Rattenborg-CoPI). The goal of both projects was to find ways to postpone temporarily the need for sleep, and do so in a way that is completely safe. In Phase I, the strategy had been to study animal models of sleeplessness, including models created through mutagenesis (flies) or naturally-occurring models (birds), in order to identify druggable targets that can be exploited.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 22, 2008
Accession Number
ADA498600

Entities

People

  • Chiara Cirelli
  • Giulio Tononi
  • Ruth Benca

Organizations

  • University of Wisconsin–Madison

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Agreements
  • Birds
  • Brain
  • Chemistry
  • Department Of Defense
  • Deprivation
  • Diptera
  • Drosophila
  • Engineering
  • Gene Expression
  • Genes
  • Health Services
  • Medical Personnel
  • Power Spectra
  • Sleep Deprivation
  • Students

Readers

  • Aerospace Engineering
  • Circadian Sleep-Wake Regulation and Chronobiology
  • Oncology