The Role of Cyclin E and its Lower Molecular Forms in the Oncogenesis of Ovarian Cancer and its Predictive Value in Patients with Early Stage Ovarian Tumor
Abstract
The deregulation of cell cycle checkpoints, with loss of regulation at the G1/S transition, has been shown to play an important role in the transformation to a malignant phenotype. Our studies have focused on cyclin E, which appears in late G1 and flanks the restriction point .We hypothesize that alterations of cyclin E in ovarian cancer cells contributes to the oncogenesis of ovarian tumors and negatively impacts outcome in patients with Stage I-III cancer. In this proposal we will i) develop a comprehensive ovarian cell line model for characterization of the role of cyclin E in ovarian cancer, ii) delineate the role of cyclin E and its tumor specific LMW forms in the development of malignant phenotype in vitro and in nude mice. iii) establish the prognostic value of the hyperactive forms of cyclin E in patients with Stage I-III ovarian cancer and iv) examine the biochemical significance of the LMW forms of cyclin E in tumor specimens. The results from our studies will provide much needed information about the molecular biology of ovarian carcinoma and may open new avenues for the development of targeted therapies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2007
- Accession Number
- ADA499449
Entities
People
- Khandan Keyomarsi
Organizations
- The University of Texas MD Anderson Cancer Center