Role of Katanin in Prostate Cancer Bone Metastasis
Abstract
In the bone marrow from prostate cancer patients with clinical evidence of bone metastasis, we identified katanin p60 as a differentially expressed factor. Our preliminary studies showed that katanin p60 is expressed in prostate cancer cell lines and also in the prostate cancer tissues of local disease and bone metastasis, suggesting that katanin p60 is associated with prostate cancer progression and metastasis in bone. We hypothesize that katanin p60 serves as a cell migration factor to mediate prostate cancer metastasis to bone. In the proposed study, we will focus on the characterization of the katanin p60 in vitro and in vivo with regards to its functions in prostate cancer bone metastasis. Our proposed study is highly relevant to prostate cancer because the katanin p60 is apparently associated with osseous metastasis. Understanding the functional mechanism of katanin p60 in prostate cancer bone metastasis will provide opportunities for therapeutic intervention. Katanin p60 can be a novel therapeutic target for prostate cancer bone metastasis, or a biomarker for early diagnosis. Therefore, the outcome of this study will help us to reduce prostate cancer related mortality.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2009
- Accession Number
- ADA499609
Entities
People
- Xiang-cang Ye
Organizations
- The University of Texas MD Anderson Cancer Center