Determination of Optimum Vitamin D Nutrition in Young Women
Abstract
The main objective of the current proposal is to study the effect of increasing doses of vitamin D3 in a group of young women with hypovitaminosis D (serum 25OHD < 20 ng/ml) and an adequate calcium intake of 1200 -1400mg/day. This is a double blind randomized placebo controlled study .There will be 5 treatment arms, four vitamin D3 dose groups ,400, 800, 1600, and 2400 IU/day and placebo .Calcium citrate tablets will be given to maintain the calcium intake between 1200-1400mg/d in all subjects. The study will recruit up to 100 Caucasian and 100 African American women subjects) between age 25 and 45. The primary outcomes are changes in serum 25OHD and serum PTH. Secondary outcomes are calcium absorption, physical performance tests and safety measurements of serum calcium and 24 hour urine calcium. Subjects will be recruited in the spring and winter seasons of two consecutive years. In the first winter active recruitment started on April 1 2008 and finished in July 2008 and the first subject was randomized to treatment on 04/28/2008. To date we have 49 subjects randomized to treatment (20 African Americans and 29 Caucasians).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2008
- Accession Number
- ADA499646
Entities
People
- John C. Gallagher
Organizations
- Creighton University