Molecular Basis of Essential Thrombocytosis
Abstract
Human blood platelets play critical roles in normal hemostatic processes and pathologic conditions such as thrombosis (i.e. cardiovascular disease and stroke), vascular remodeling, inflammation, and wound repair. Despite the biological importance of platelets and their intact protein synthetic capabilities, remarkably little is known about platelet mRNAs. The pathogenesis of essential thrombocytosis (ET), a disease of platelet number and function, is poorly understood at the molecular level. The main goal of this project is to build on our preliminary data that suggests that patients with ET have distinct platelet transcript profiles that differ from those of normal platelets. The three main hypotheses to be tested are: (1) patients with ET have mRNA profiles that are distinct from those of normal controls; (2) these differences can be used to elucidate the molecular basis of ET; and (3) these differences can be used to differentiate ET from other causes of thrombocytosis (ET diagnostics). Completion of the specific aims as outlined below should (i) provide considerable insight into the molecular basis of ET, (ii) assist with molecular diagnostics, and (iii) help to devise rational approaches for pharmacological intervention.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2008
- Accession Number
- ADA499651
Entities
People
- Wadie F. Bahou
Organizations
- State University of New York