Rapid Altitude Acclimatization

Abstract

The goal of this seedling was to determine whether cell-free hemoglobin (HBOC) solutions could enhance oxygen carrying capability of blood during exposure to high altitude (14,000 ft and above). The outcome of interest was increased altitude exercise performance secondary to improved oxygen carrying capacity of blood. Male Sprague Dawley rats were habituated to treadmill running, then evaluated on time to fatigue at base altitude (1500 m) and then again at 4300 m. Running times were reduced for rats at altitude. Treatment with HBOC worsened running times by ~50%, despite increased oxygen carrying capacity of blood. This led to an investigation as to cause and to possible interventions.

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Document Details

Document Type
Technical Report
Publication Date
May 09, 2008
Accession Number
ADA500150

Entities

People

  • David Irwin
  • Karyn Hamilton
  • Martha Tissotvanpatot
  • Robert Gotshall

Organizations

  • University of Colorado Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Acclimatization
  • Agreements
  • Altitude
  • Altitude Acclimatization
  • Cardiovascular Physiological Phenomena
  • Department Of Defense
  • Education
  • Growth Factors
  • Hemoglobin
  • High Altitude
  • Infusions
  • Inhibitors
  • Payload
  • Proteins
  • Side Effects
  • Students

Readers

  • Cardiovascular Physiology
  • Exercise and Sports Science.
  • Geospatial Intelligence and Artificial Intelligence Analytics