Control of Growth Within Drosophila Peripheral Nerves by Ras and Protein Kinase A

Abstract

The long term goals of this research are to understand the mechanisms by which NF1 and its partners control growth using the Drosophila peripheral nerve as our assay system. This system is advantageous because we can apply a number of powerful molecular genetic methodologies that are not available in other systems. Our major findings were generated from aim #4. We reported after year2 that Ras nonautonomously activates perineurial glial growth via PI3 Kinase, Akt and FOXO (published in the Journal of Neuroscience in 2007). Second, we report preliminary evidence that pushover (push) acts in the glia to regulate perineurial glial growth, but in the neuron to regulate excitability. Third, we report that activation of the Tor pathway is necessary but not sufficient to increase perineurial glial growth. Fourth, we report that the metabotropicglutamate receptor regulates neuronal growth and excitability via PI3K.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2009
Accession Number
ADA500671

Entities

People

  • Michael Stern

Organizations

  • Rice University

Tags

DTIC Thesaurus Topics

  • Autism
  • Biochemistry
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epilepsy
  • Genetics
  • Growth Factors
  • Nervous System
  • Neuroglia
  • Neuromuscular Diseases
  • Peptide Growth Factors
  • Peptides
  • Peripheral Nervous System
  • Proteins
  • Skin Diseases

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology