Early Prediction of Lupus Nephritis Using Advanced Proteomics
Abstract
The survival with Systemic Lupus Erythematosus (SLE) is closely linked to the early detection of kidney disease, making the discovery of currently elusive renal biomarkers crucial for the prognosis of SLE. A well-defined cohort of patients with SLE (n=150), disease and healthy controls were assembled and followed-for up to 1.5 years. By surface-enhanced laser desorption time to flight mass spectrometry (SELDI-TOF-MS) and matrix enhanced various TOFMS, we discovered a set urinary lupus nephritis candidate biomarkers; namely transferring, ceruloplasmin, alpha1-acid glycoprotein, and lipocalin-like prostaglandin-D synthetase. Urinary concentrations of these lupus nephritis candidate biomarkers differed significantly with the presence of lupus nephritis. The accuracy of these lupus nephritis biomarkers to detect a flare of disease as measured by the area under the receiver operating characteristic curve was at 0.85 excellent. Thus we characterized a novel panel of urinary markers whose preliminary study supports them being excellent biomarkers of the course of lupus nephritis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2008
- Accession Number
- ADA500881
Entities
People
- Prasad Devarajan