Involvement of Novel Multifunction Steroid Hormone Receptor Coactivator, E6-Associated Protein, in Prostate Gland Tumorigenesis

Abstract

E3 ubiquitin-protein ligase enzyme, E6-associated protein (E6-AP), is a novel dual function steroid hormone receptor coactivator. Previously I have shown that E6-AP regulates PI3K-Akt pathway in the prostate gland and as well as LNCaP cells. In this report I have provided evidence that E6-AP plays a vital role in the prostate gland growth and prostate cancer cell proliferation. E6-AP by itself can modulate p53 levels in prostate cancer cells independent of E6. Our data also indicates that over expression of E6-AP could potentially lead to tumor initiation. I have also shown that E6-AP also affects the non-genomic mechanisms of AR. ChIP assays demonstrate that AR is accumulated on its target promoter and enhancer under E6-AP knockdown conditions. Taken together, these studies indicate that E6-AP plays a vital role in both the genomic and non-genomic signaling pathway of AR and their downstream effectors might play critical roles in many biological processes, especially in cell growth.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2009
Accession Number
ADA500946

Entities

People

  • Sathish Srinivasan

Organizations

  • University of Miami

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Biological Processes
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Gene Expression
  • Glands
  • Hormones
  • Neoplasms
  • Papillomavirus Infections
  • Prostate Cancer
  • Prostate Gland
  • Proteins
  • Tissues

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).