Multidisciplinary Analysis of Cyclophilin a Function in Human Breast Cancer

Abstract

The major goal of the proposed project is to understand how cyclophilin A (CypA) modulates the prolactin (PRL) receptor (PRLr)-associated signaling and to determine the effects of altered CypA levels and activity on PRL signaling and breast cancer phenotype by combining biophysical structural investigations with studies in cell and animal models. The knowledge we obtained from this study will contribute to a greater understanding of the mechanism of PRL action. Our recent data suggest that CypA, serving as a molecular switch via its peptidyl-prolyl isomerase (PPI) activity, binds to and regulates the function of the PRLr through its X-box motif. From a translation perspective, we have also shown that the X-box peptide significantly blocks PRLr signaling. Given that the PRLr-triggered signals directly contribute to PRL-induced proliferation, survival, and motility of human breast cancer, the proposed study in detail on the effect of CypA on PRLr structure and function will have a significant impact on human breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2009
Accession Number
ADA500989

Entities

People

  • Jiamao Zheng

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Blood
  • Breast Cancer
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Growth Factors
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Three Dimensional

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech