PCBs Alter Dopamine Mediated Function in Aging Workers
Abstract
The major hypothesis is that prior occupational exposure to polychlorinated biphenyls (PCBs) results in decrements in neuropsychological and neurological performance and the number of dopamine (DA) terminals in the basal ganglia determined by Beta-CIT SPECT imaging. Data collection is complete (a comprehensive questionnaire, examinations and SPECT imaging). PCBs and thyroid hormones have been measured in serum and bone lead has been determined. Results, obtained using Beta-CIT SPECT imaging demonstrate a significant negative relationship between current serum PCB concentrations and decreases in the density of Beta-CIT binding only in women. Serum PCB concentrations have decreased 10-fold from peak values during occupational PCB use, but remain elevated (two-fold) compared to a similar-aged non-occupationally exposed population. Estimating PCB half lives using analysis of both current and archived serum samples revealed significantly longer half lives for PCB congeners of occupational origin in women compared to men. Data analysis and manuscript preparation continues for neurological and neuropsychological endpoints.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2009
- Accession Number
- ADA501075
Entities
People
- Richard F. Seegal