The Role of ERBP in Breast Cancer Progression
Abstract
Metastasis likely occurs when primary tumor cells obtain additional genetic or epigenetic alteration. ERBP (estrogen receptor binding protein) is an estrogen receptor binding protein which potentiates the transcriptional activity of estrogen receptor. Unlike most coactivators which interact with AF2 domain of estrogen receptor, ERBP interacts with the DNA binding domain of estrogen receptor. The altered expression of ERBP could promote the metastasis through enhancing the expression of genes which are regulated by estrogen and are involved in the breast cancer metastasis. By overexpressing ERBP in breast cancer cells, we found that ERBP overexpression enhanced the migration and invasion capability of tumor cells. ERBP overexpression also promoted the tumor formation in nude mice. We identified 8 estrogen inducible genes which were up-regulated by ERBP overexpression. Finally, we found that expression of ERBP is increased in about 30% of breast cancers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2008
- Accession Number
- ADA501116
Entities
People
- Yijun Zhu
Organizations
- Northwestern University