Evaluating the Role of Genetic Markers in Prostate Cancer Progression: A Multiethnic Cohort Experience
Abstract
Most prostate cancer (PCa) research has focused on risk, little is known about predictors of progression and even less about how these factors differ by ethnicity/race. Strong racial disparities in mortality have shown that African-Americans are twice as likely to die from PCa compared to Caucasians; very little data are available in Hispanics. Our overall goal is to identify markers related to PCa progression in a multiethnic cohort of 773 Caucasians, 361 African-Americans, and 246 Mexican-Americans, for whom we have already collected information. We have abstracted medical records for 735 patients and are now requesting copies of outside medical records for those who received care outside our institution, as well as continuing to abstract medical records. Additionally, we are preparing a request for vital status from the National Death Index to obtain information on cause of death. Genotyping assays have been established in the Genotyping Core, and DNA has been extracted from 90% of the patients? blood. Our research may help explain ethnic/racial disparities in PCa progression and provide direction towards eliminating these disparities and may guide future studies to develop ethnic/racial specific interventions to improve outcome in the most common cancer in American men.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2008
- Accession Number
- ADA501173
Entities
People
- Sara S. Strom
Organizations
- The University of Texas MD Anderson Cancer Center