Implantable Microsystems for Anatomical Rewiring of Cortical Circuitry: A New Approach for Brain Repair
Abstract
Our first-generation electronic microsystem is tested successfully in an anesthetized rat model by recording neural spikes from the somatosensory cortex of the brain, and stimulating the primary motor cortex that results in clear wrist movements. Using a controlled cortical-impact device, we have successfully induced traumatic brain injury (TBI) in the caudal forelimb area of the rat brain, sparing the rostral forelimb area that is the target for implantation of the electronic microsystem. We have demonstrated that a wide range of impact parameters satisfy the requirements of the study for post-TBI implantation of the device. Behavioral assessments of reaching, retrieval of small food items, and locomotion demonstrate that deficits persist during the 5-week recovery period following injury. This will provide us with an ideal time window during which to test the effects of the device after injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2009
- Accession Number
- ADA501262
Entities
People
- Meysam Azin
- Pedram Mohseni
Organizations
- Case Western Reserve University