Catalytic Bioscavengers Human Butyrylcholinesterase and Paraoxonase Sequestered to the Center for CNS

Abstract

The purpose of this research is to genetically engineer, express, and validate 2 novel biopharmaceutical fusion proteins, designated AGT-185 and AGT-186. Both proteins are fusion proteins of human paraoxonase (PON)-1 variants and a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR). The 2 proteins are intended for development as new treatments of the brain in organophosphate chemical nerve gas attacks.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2009
Accession Number
ADA501313

Entities

People

  • Ruben J. Boado

Tags

DTIC Thesaurus Topics

  • Acids
  • Amino Acids
  • Antibodies
  • Blood
  • Blood-Brain Barrier
  • Brain
  • Cells
  • Central Nervous System
  • Chemical Compounds
  • Deoxyribonucleic Acids
  • Monkeys
  • Organophosphates
  • Proteins
  • Rhesus Monkeys
  • Transfection
  • Transport Ships
  • Trojan Horse

Fields of Study

  • Biology

Readers

  • Immunology
  • Neurotoxicology
  • Software Engineering

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech