Free Radical Damage and Noise-Induced Hearing Loss: in vivo in situ Sensing

Abstract

Noise-induced hearing loss (NIHL) is one of the most pervasive sources of reduced auditory acuity, the biochemistry of which is incompletely understood. We hope to clarify the role of reactive oxygen species frequently associated with NIHL, and in the process demonstrate technology generally applicable to studying small-molecule chemistry in the inner ear. Inner ear structures (cochlea) show evidence of damage by ROS correlated with NIHL. It is unclear whether this damage CAUSES hearing loss or is a CONSEQUENCE of the processes leading to such loss. Our goal has been to develop, validate, and employ unique chemical sensors, implanted in laboratory animal cochlea, to measure ROS in real time. This may lead to development of strategies to optimize pharmaceutical intervention to minimize NIHL.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2008
Accession Number
ADA501567

Entities

Organizations

  • University of Illinois Urbana–Champaign

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Cells
  • Chemical Compounds
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Detectors
  • Ear
  • Free Radicals
  • Hearing Disorders
  • Hearing Loss
  • Oxygen

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Combustion science or combustion engineering.
  • Systems Analysis and Design