Molecular MR Imaging of Protease Activity in Breast Cancer with Activated Contrast Agents

Abstract

We synthesized and characterized a smart MR contrast agent activated by Cathepsin-D enzyme. The agent was tested in a cell free system and in vitro with immobilized breast cancer cells. We also initiated animal studies however due to the finding that the structure of the probe needs to be optimized we are currently refining the agent for in vivo applications.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2008
Accession Number
ADA501588

Entities

People

  • Dmitri Artemov
  • Yoshinori Kato

Organizations

  • Johns Hopkins University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Contrast
  • Cultured Cells
  • Diseases And Disorders
  • Magnetic Resonance
  • Materials Processing
  • Metal Oxide Nanoparticles
  • Molecular Weight
  • Nanoparticles
  • Neoplasms
  • Particles
  • Prostate Cancer
  • Tumor Cell Line

Fields of Study

  • Physics

Readers

  • Agent-Based Social Robotics and Mobile-Assisted Learning in Virtual Environments.
  • Medical Imaging.
  • Molecular and Cellular Biochemistry