Novel and Efficient Synthesis of the Promising Drug Candidate Discodermolide
Abstract
During the third year of this grant, we optimized a new preparation of the "stereotriad building block" and studied the underlying chemistry for the new scheme. We also discovered and studied the one step, direct iododesilylation of dihydrooxasilines, a reaction that can be used to shorten our new scheme. In addition, we studied model conversions for a scheme that will convert a by-product from our degradation of oleandomycin to a useful "building block" for discodermolide. Thus, the oleandomycin degradation can supply two of the three synthons required for the total synthesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2009
- Accession Number
- ADA501895
Entities
People
- Kathlyn A. Parker
Organizations
- State University of New York