Toxicity in Rhesus Monkeys Following Administration of the 8-Aminoquinoline 8-[(4-amino-l-methylbutyl)amino]-5(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511)
Abstract
Many substances that form methemoglobin (MHb) effectively counter cyanide (CN) toxicity. Although MHb formers are generally applied as treatments for CN poisoning, it has been proposed that a stable, long-acting MHb former could serve as a CN pretreatment. Using this rationale, the 8-aminoquinoline WR242511, a potent long-lasting MHb former in rodents and beagle dogs, was studied in the rhesus monkey for advanced development as a potential CN pretreatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2008
- Accession Number
- ADA502028
Entities
People
- Anita V. Moran
- Crystal M. Briscoe
- David W. Kahler
- Gary A. Rockwood
- Kevin R. Armstrong
- Mark B. Gold
- Steven I. Baskin
- Steven M. Duniho
Organizations
- United States Army Medical Research Institute of Chemical Defense