The Role of Androgen Receptor-Target Genes in Racial Disparity of Prostate Cancer
Abstract
The award is transferred to the PI 10/1/08. During this short period, we identified a novel androgen responsive element in the promoter region of cyclinB1 that negatively regulates its expression in AR-positive prostate stromal cells. Cyclin B1 expression is maintained by E2F1 in prostate stromal cells in the absence of androgen. Upon stimulation with androgen, E2F1 is displaced from the promoter by E2F4, leading to recruitment of the SMRT co-repressor complex, and repression of cyclin B1 expression. These results strongly indicate cyclin B1 as a bona fide AR target gene negatively controlled by androgen-dependent E2F regulation. Next, we will determine the association between stromal cyclinB1 expression and prostate cancer racial disparity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2008
- Accession Number
- ADA502322
Entities
People
- Patrice S. Pearce
Organizations
- New York University